Understanding the role of genetics in depression, substance use

Graduate student receives award for early career research on mental health and substance abuse

February 3, 2023

According to the National Center for Drug Abuse Statistics, over 50% of teenagers report misusing drugs at least once, and 62% of high school seniors report having abused alcohol. In addition, a recent report from the American Psychological Association highlights that racial and ethnic minority adolescents have to contend with stressors related to multiple minoritized identities (i.e., socioeconomic status, documentation status), which increases their risk for the development of substance-use problems and depression or anxiety. 

Belal Jamil is an Arizona State University doctoral psychology graduate student specializing in the developmental psychology training area. He hopes to better understand how genetics, cultural factors, family processes and parenting can influence substance use and the development of depression and anxiety in adolescence and emerging adulthood (18–26 years).
ASU grad student Belal Jamil smiling at the camera in an outdoor setting. Belal Jamil, an ASU doctoral psychology graduate student specializing in the developmental psychology training area, hopes to use his research to both inform future projects but also to motivate interventions for minority populations. Photo courtesy the Department of Psychology Download Full Image

“I’m specifically interested in that age range because that's when a lot of these problems start to develop,” Jamil said. “Many intervention approaches have been very helpful and useful, but they've only been tested within these specific demographics. There are different cultural or family values that exist within other cultural, racial or ethnic groups, and those can have a much more significant impact on the success of these different interventions.”

Jamil is a second-generation Pakistani American and recently received the Cialdini Developmental Psychology Early Graduate Career Award, which recognizes his excellent scholarship and early career research. Additionally, he recently applied for an NSF fellowship for his work on promoting health and well-being among underserved populations. 

“My research interest is kind of niche — I want to look at behavioral genetics, or how genetics influence people's psychological development and substance use. Specifically, I want to look at that question within ethnic minority populations because right now in ... literature, a lot of the focus is on people of European ancestry and predominantly white populations. This doesn't really translate as well to other ethnic and racial groups,” Jamil said.

Jamil is mentored by Jinni Su, an assistant professor who leads the Genes, Environment, and Youth Development lab. Su recently published a study about the link between personality, genetics, racial discrimination and problematic drinking, and has begun to translate addiction and mental health research for the Chinese American population. 

“Belal is purely amazing! His award is well deserved, and will provide important support as he continues his impactful research on understanding pathways of risk and resilience to substance use and mental health outcomes among minoritized populations,” Su said. 

Su and Jamil recently began working on research about the bidirectional impacts of adolescent depression on teens and their parents. Past research suggests that parental depression can negatively impact teenagers, but it is also possible that teenagers’ depression can negatively impact their parents’ mental health.

“One of the studies that we're working on right now is looking at things like substance use and mental health outcomes among white students and non-white, minority college students, and really looking at that within the context of COVID,” Jamil said. “We're hoping to see how different factors might influence variations and like adjustment and ability to cope with COVID.”

In a similar study about the stress of transitioning into college, Jamil and Su also found that among white participants, a romantic partner’s social support was associated with lower depression, but that same association wasn’t found among minority students, suggesting that within the transition to college, there might be differences in the amount of social support available, and romantic relationships did not mitigate that stress in some populations. 

Jamil hopes to use his research to both inform future projects but also to motivate interventions for minoritized populations. 

“As of right now, my goal with research is to inform these intervention and prevention efforts that we have,” Jamil said, “specifically with things like substance use — that's really a big problem on college campuses, and especially in the context of COVID-19, we see increases in things like alcohol use and in smoking and cannabis use. Because of that, I think it's really important to understand how it might not be that ‘one-size-fits-all approach’ and instead look at how these pathways might be different depending on upbringing and background.”

Robert Ewing

Marketing and Communications Manager, Department of Psychology


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First-of-its-kind instrument officially ushers in new era of X-ray science

February 3, 2023

ASU's compact light source instrument makes its first X-rays

Arizona State University has officially begun a new chapter in X-ray science with a newly commissioned, first-of-its-kind instrument that will help scientists see deeper into matter and living things. The device, called the compact X-ray light source (CXLS), marked a major milestone in its operations as ASU scientists generated its first X-rays on the night of Feb. 2.

“This marks the beginning of a new era of science with compact accelerator-based X‑ray sources,” said Robert Kaindl, who directs ASU’s Compact X-ray Free Electron Laser (CXFEL) Labs at the Biodesign Institute and is a professor in the Department of Physics. “The CXLS provides hard X-ray pulses with high flux, stability and ultrashort durations, in a very compact footprint. This way, matter can be resolved at its fundamental scales in space and time, enabling new discoveries across many fields — from next-generation materials for computing and information science, to renewable energy, biomolecular dynamics, drug discovery and human health.”

Building the compact X-ray light source is the first phase of a larger CXFEL project, which aims to build two instruments including a coherent X-ray laser. As the first-stage instrument, the ASU CXLS generates a high-flux beam of hard X‑rays, with wavelengths short enough to resolve the atomic structure of complex molecules. Moreover, its output is pulsed at extremely short durations of a few hundred femtoseconds — well below a millionth of one millionth of a second — and thus short enough to directly track the motions of atoms.

Such capabilities have so far only been available at large X-ray free-electron laser (XFEL) facilities, whose number has been limited to only a handful of sites worldwide due to their size and billion-dollar level construction costs. Here, the ASU device provides a uniquely compact facility for ultrashort X-rays that fits into the size of a basement, making leading-edge X-ray science accessible to a university campus.

Under the surface

X-rays have long propelled medical and scientific discoveries far beyond what we can see with the naked eye. Applications transcend the scales, from X-ray astronomy to peer at the universe, to X-ray medical imaging at the human scale, down to resolving complex materials and biomolecules at their atomic scale. Such methods however remained largely static, keeping hidden the ultrarapid dynamics at the heart of proteins at work in our bodies and many other processes in matter.

Only recently researchers have been able to access such dynamics with ultrashort X-ray pulses as generated by XFELs. These ultrashort X-ray pulses can capture atomic-scale molecules akin to how photographers can make a still picture of a hummingbird’s wings via the short bursts of strobe lights used in high-speed photography. Moreover, ultrashort X-rays enable new ways to capture structures of proteins that are otherwise difficult to crystallize.

Here, ASU’s compact X-ray light source will provide key capabilities to help understand both the three-dimensional arrangement and motions of atoms, helping to resolve protein function or advance drug discovery by seeing how a drug interacts with its molecular target, for example.

“This is giving us a new tool to look at medical science and semiconductors and all kinds of imaging in different ways,” said William Graves, the project’s chief scientist, director of accelerator science at the Biodesign Institute and a professor in ASU’s College of Integrative Sciences and Arts. “What this machine allows us to do is see soft tissue changes. We can see blood flowing in blood vessels. We can see individual nerves. We can see down to the cellular level.”

The new ASU CXLS facility includes three main components:

• A table-top particle accelerator that produces a stable electron beam with energies reaching up to 30 million (30 MeV) electron volts.

• A high-powered infrared laser that interacts with the electron beam, in turn producing ultrashort hard X-ray pulses with up to 20 keV photon energy.

• Science experiment chambers and a tunable excitation laser to carry out studies of X-ray interactions with a wide variety of research targets.

A science magic trick

To make the first X-rays, the CXLS instrument was powered up to deliver around 4 keV photon energy. The first step takes place in the photoinjector of the light source. There, UV laser pulses are applied to a copper surface — at a rate of 1,000 pulses per second — each releasing a bunch of electrons into vacuum which are then accelerated in a strong electric field. Next, the electron bunches are driven by a linear accelerator to nearly the speed of light and travel through a series of magnets that guide and focus the beam into an interaction chamber.

In the final step, an infrared laser is shot nearly head-on into the path of the oncoming electrons. This results in the emission of powerful X-rays, in a process known as inverse Compton scattering, where the laser is key to the compact facility size. Strong magnetic fields shepherd the electrons into a capture sink. The emitted X-rays are sent downstream to interact with the sample of interest, such as proteins or other molecules (for the first X-ray demonstration, this step was omitted).

The experiment was performed and confirmed by detecting light emission from a YAG scintillator screen. Scientists watched and monitored the beam activities and confirmed the generation of X-rays in their data analyses. 

“I am intrigued by technical innovations that greatly shrink the size and cost of these machines,” Graves said. “Turning on this novel light source represents the culmination of a decade of groundwork, from theory to design to build out, all the while overcoming obstacles such as supply-chain delays and other disruptions due to the worldwide pandemic.”

Extensive engineering efforts were required to realizing this novel instrument, led by the project’s chief engineer and deputy director Mark Holl. At ASU, the team partnered with ASU’s Instrument Design and Fabrication Core in the precision fabrication of thousands of component parts required for final beamline and instrument assembly.

“The CXLS will be a boon to a wide range of imaginative scientists working to unlock the secrets of biology, chemistry and physics. We are quite excited to reach this important milestone and eager to begin the experimental era of compact X-ray accelerator science,” Graves said.

Infographic explaining first phase of ASU's CXFEL program
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A new era begins

The CXLS is now being readied for its first series of experiments. To do so, ASU researchers have been building an advanced experimental setup for X-ray crystallography. The X-ray pulses travel along a "beamline" through a lead-shielded cutout window from the source to the adjacent user hutch room and into the science experiment chamber.

The setup provides precision nanoscale sample positioning and injection capabilities, along with a high‑resolution 4-megapixel X-ray detector, which can capture every X-ray shot. Moreover, a tunable excitation laser — funded by a National Science Foundation MRI grant — provides tailored photoexcitation for time-resolved studies.

Among the scientists eager to embark on the first experiments is ASU’s Petra Fromme, a leading expert at understanding how life’s processes work at the molecular level.

Fromme, along with her late ASU colleague John Spence and with Henry Chapman at the German DESY electron synchrotron center in Hamburg, co-developed the core methods of serial femtosecond crystallography used at today’s big XFELs worldwide.

“It was clear from the beginning this would be the first instrument of its kind in the world,” Fromme said. “Without President Crow’s huge commitment to the Biodesign C building and initial funding of $9 million, we would never have gotten the program off the ground. And then, on a plane, I met (the late) Leo Beus without knowing who he was. He and his wife, Annette, made a $10 million donation for CXFEL Labs.”

Fromme plans to apply the CXLS to explore the most fundamental steps in how plants convert sunlight to energy during photosynthesis, insights which may help create artificial photosystems for more efficient and renewable energy conversion.

“My real motivation is still the holy grail of photosynthesis, which at its core has not been solved,” Fromme said. “How do plants split water into oxygen, protons and electrons using visible light and Earth-abundant metals? When we discover how plants do that, then we could build systems which are as efficient as nature and as stable as artificial systems.”

Already, the new instrument has served as a beacon in recruiting new scientists to ASU, like Department of Physics Assistant Professor Sam Teitelbaum.

“My research uses free electron lasers, tabletop lasers and synchrotrons to understand how materials transform,” Teitelbaum said. “Using the new compact X-ray source, we can learn a lot about the properties of matter by observing it on the very fast time scales their individual molecules operate on.”

Broadening access to advanced X-ray science

The ASU instrument will serve the broader research community. One of the CXLS instrument’s main benefits to the nation is expanding access to — in essence "democratizing" — the science of ultrashort X-rays, so that other universities or labs may use the ASU facility or develop similar technology. This increased access will help speed up and advance critical areas of science and broaden the user base for large XFELs.

The CXLS will be available to serve scientists from all over the U.S., be a training ground for ASU students and attract international scientists. Together, this next generation of X-ray scientists can multiply the scientific discoveries and exploration of the structures and dynamics of inside living things, molecules and materials.

“I’m most intrigued by what lies at the edge of our knowledge, pursuing phenomena that have never been observed before,” said Kaindl. “Now we have all the means to do so. With the conclusion of the compact X-ray light source commissioning, our focus will shift to early experiments with its ultrashort X-rays and the transition to a user facility.”

The first set of experiments are scheduled to begin later in 2023.

Video by Ken Fagan/ASU News

Top photo: ASU Department of Physics Assistant Professor Samuel Teitelbaum stands in front of a newly commissioned, first-of-its-kind instrument that will help scientists see deeper into matter and living things. The device, called the compact X-ray light source (CXLS), marked a major milestone in its operations as ASU scientists generated its first X-rays on the night of Feb. 2. Photo by Andy DeLisle/ASU.

Joe Caspermeyer

Manager (natural sciences) , Media Relations & Strategic Communications