image title

Rapid testing to the rescue

September 28, 2020

When the COVID-19 pandemic arrived, researchers at the Biodesign Institute leapt into action

Editor's note: This story originally appeared in the fall 2020 issue of ASU Thrive magazine. 

On the morning of March 11, clinicians at the Arizona Department of Health Services reported three new cases of the novel coronavirus in the state, and Gov. Doug Ducey declared a public health emergency. 

Dr. Joshua LaBaer, executive director of the Biodesign Institute at ASU, was in his office when he heard about Ducey’s declaration. LaBaer spends a lot of his time thinking about infectious disease even when there’s not a pandemic, and yet the novel coronavirus was unlike anything ever seen. 

“We took it very seriously,” LaBaer said. “Our epidemiologists were saying this is going to spread.” 

But in the emerging crisis, he saw an opportunity to save lives. 

Making rapid saliva tests

Founded in 2003, the Biodesign Institute with its 17 research centers has a broad mandate to conduct research at the intersection of global health, sustainability and security. In March 2020 it was clear that widespread and rapid testing would be critical to combat the novel coronavirus, and that LaBaer’s team was well-equipped to make that happen. 

Joshua LaBaer

Biodesign Institute Director Joshua LaBaer in one of the testing labs.

Before the pandemic, LaBaer’s group won a contract from the Department of Defense’s Biomedical Advanced Research and Development Authority, or BARDA, to develop tests that could quickly identify the level of radiation exposure in individuals. These tests were meant to save lives in dangerous, rapidly developing situations like a nuclear accident, but many of the techniques and equipment could also be used to detect a coronavirus infection. 

“We had the equipment, the expertise and the knowledge to pivot to COVID-19 testing,” LaBaer said.

First his team started with nasopharyngeal swab tests, but within weeks made the decision to start developing saliva tests instead. Spitting in a tube doesn’t involve the same physical discomfort that sticking a long swab up your nose does, which could encourage more people to get tested. The novel saliva tests are faster and more cost-effective because they don’t require trained medical staff to administer. 

“You can scale up saliva tests,” LaBaer said. 

Building a medical laboratory

Prior to the pandemic, the institute was purely a research facility; it wasn’t designed to handle clinical work, which requires equipment, personnel and procedures that meet stringent federal regulations. LaBaer tapped Dr. Carolyn Compton, who is trained as a clinical pathologist, to lead the transition.

“There was no medical laboratory at the Biodesign Institute, so we had to create it,” said Compton, a professor in the School of Life Sciences who now serves as the institute’s medical director. 

Rapidly pivoting a lab from academic to clinical work would be a Herculean task even under normal circumstances, but the fact that a lot of this clinical work would have to happen under extremely unusual clinical conditions, like taking samples from participants while they sat in their cars in a parking lot, added to the complications. 

Compton’s main duty was making sure the lab met the strict standards of the Clinical Laboratory Improvement Act that governs how labs that produce medical data must monitor and verify the people and instruments doing the tests.

“We have to record every temperature change and every deviation of the performance of our equipment,” Compton said. “CLIA inspections are a very serious thing.” 

And since the lab wouldn’t just be doing analysis but handling sample collection and distribution of results as well, that also meant designing a workflow that is compliant with federal privacy laws from start to finish. For Compton and her team, that meant mountains of additional paperwork and still more training for research staff to ensure patient privacy. 

Compton’s extensive experience as a clinical pathologist made it possible to rapidly transition LaBaer’s lab to a clinical testing facility. But she says she wouldn’t have taken on this weighty responsibility in the first place if LaBaer hadn’t already laid the foundation for the initiative’s success. She says the lab’s previous work with BARDA enabled its fast pivot to COVID-19 testing because it meant LaBaer and his team were already familiar with the stringent federal requirements for operating a clinical lab.

"Turnaround time is key. If results take a week then it’s going to be too late. Testing is only an intervention if you can get an answer back to somebody quickly.”  

— Biodesign Director Joshua LaBaer

“Many academic labs are purely discovery labs and don’t do product development for deployment to the health care system,” Compton said. “Josh’s laboratory wasn’t just sophisticated in terms of its technology, it was sophisticated in terms of its knowledge of regulatory requirements.” 

By May, Biodesign Institute researchers had successfully created the first saliva-based COVID-19 test in the state. Soon after, they began piloting the test with a network of first responders in Phoenix who were at the greatest risk of exposure to the virus. By comparing the results of these tests with nasopharyngeal swabs from the same individuals, the Biodesign Institute found that the saliva-based tests were just as accurate. 

The Biodesign Institute expanded its saliva test network to include students and employees, and soon was processing up to 1,400 samples a day. By early July, the diagnostic system rolled out to the general public, and ASU announced a partnership with the Arizona Department of Health Services to set up testing sites in underserved communities around the state. The goal of this $12.7 million partnership is to provide free saliva tests for up to 100,000 Arizonans. 

In a press release when the collaboration was announced, Gov. Doug Ducey said: “This critical partnership will have an immediate impact in the fight against COVID-19 and help us surge testing where it’s needed most. My thanks to Arizona State University for their continued partnership and for continuing to step up to aid public health in innovative and invaluable ways.”

Setting up testing sites without tying up health care workers

Dorinda Wilson is an events manager at ASU, and she’s been helping many of the university’s partners organize COVID-19 testing sites since the beginning of April. Wilson heads a team of fewer than 10 people, and the events they run usually don’t involve testing people or donning head-to-toe personal protective equipment. But the same sorts of logistical skills still apply. 

“Events people know how to work under pressure and think on our toes,” Wilson said. “That mindset works in this pandemic, and we bring that skill set to the testing sites.” 

ASU's Breanna Carpenter conducts daily COVID-19 saliva-testing training

Instead of planning events like homecoming and ASU Open Door, Breanna Carpenter now gets up every morning at 2:30 a.m. to be at a saliva-testing site early enough to set everything up before the clinical crew arrives at 6 a.m. for daily training.

So when the Biodesign Institute contacted Wilson to ask for help setting up and running saliva testing sites, she and her team were ready.

For weeks the events team had been using the Biodesign Institute auditorium to train other organizations to set up testing facilities of their own. And starting in July, the team has also been managing the two public testing sites — one at the Cardinals football stadium and the other at Ak-Chin Pavilion — created through the university’s partnership with the Arizona Department of Health Services, where they’re responsible for safely collecting the samples and getting them back to the institute for testing.  

“Events people know how to work under pressure and think on our toes. That mindset works in this pandemic, and we bring that skill set to the testing sites.”

— Dorinda Wilson, events manager at ASU

LaBaer estimates that the institute conducted around 10,000 saliva tests during the first few weeks of the public program. It typically takes less than 48 hours for ASU to return results, versus the seven to 12 days, according to The New York Times, that it was taking large commercial lab companies in July.

“Turnaround time is key,” LaBaer said. “If results take a week then it’s going to be too late. Testing is only an intervention if you can get an answer back to somebody quickly.”  

By mid-August, LaBaer expected the institute to have more than quadrupled its testing capacity. He said it was aiming for around 16,000 tests per day. 

Data modeling

The fight against COVID-19 includes Biodesign Institute data models that serve many purposes. At the most basic level, they help keep the public informed about the virus’s trajectory in Arizona on an interactive COVID-19 dashboard on the Biodesign Institute’s website. Created in March, it’s updated daily with case counts, deaths and daily tests. 

The models also help public health officials get ahead of hot spots. Timothy Lant, director of program development for ASU Knowledge Enterprise and an applied mathematician, has been working closely throughout the pandemic with officials from Maricopa County and the Arizona Department of Health Services to help them with their modeling to stay ahead of the virus. 

The models also help inform policy decisions about things like when it’s safe to reopen businesses or whether wearing masks in public should be mandatory. 

Abba Gumel, a foundation professor of mathematics at ASU, describes his research as “the use of mathematics to save lives.” His models have largely focused on the effectiveness of nonpharmaceutical interventions like masks and physical distancing for fighting the virus. 

His results have been unambiguous: Wearing masks works, and if it had been implemented sooner in Arizona it could have saved hundreds of people from dying. Gumel collaborated with several colleagues and students from ASU on his work, including Matthew Scotch, assistant director of the Biodesign Center for Environmental Health Engineering and an associate professor at the College of Health Solutions. Gumel says his research couldn’t have happened without the support of a university that prioritizes transdisciplinary collaboration.

“ASU is gaining the reputation now as a world-class center for research in mathematical biology,” Gumel said. “It’s one of the best places to use mathematics to understand how diseases spread and how to control them, and that’s because it’s not something that can be solved by public health people, modelers, mathematicians or computer scientists alone. It requires people from different disciplines to work together.” 

Using interdisciplinary approaches

Biodesign Institute researchers have also been supported by other ASU departments. In late March, the College of Health Solutions announced it would award up to $100,000 for transdisciplinary pandemic-related research projects. One of the five grants of $20,000 was awarded to ASU’s Matthew Scotch to create a genome repository of the virus from patients with COVID-19 in Arizona. This will help researchers monitor changes in the virus’s RNA to understand how the virus evolves. 

“The College of Health Solutions is designed to really make a difference in health outcomes, and to really serve the community,” said the college’s dean, Deborah Helitzer. “And with COVID-19 there was a tremendous opportunity to rally the faculty around a topic and to bring together all of our transdisciplinary work.”

saliva testing

An example of the saliva-collection vial and straw that participants receive at ASU testing sites. Photo by Charlie Leight/ASU Now

Serving Arizona

The university’s response to the crisis helped to bring down cases through aggressive and rapid testing that delivers a result in 48 hours or less. Other reasons for the decline in cases include modeling that supports the use of face coverings and modeling that supports physical distancing. From a peak of a seven-day moving average of 3,800 new cases in July, Arizona had a seven-day moving average of 435.6 new cases a day on Sept. 10. 

ASU’s response hinged upon the institute’s ability to rapidly leverage the expertise of dozens of researchers to save lives. This was largely possible because of research grants and programs like Arizona’s Technology and Research Initiative Fund, a critical source of funding that comes out of a voter-approved sales tax. As LaBaer said, “The institute was built on TRIF.” 

“We are members of the community, we have family here,” LaBaer said. “Doing things like opening public testing sites and developing tools that the public can use helps keep that community safe. We’re here to help, and we take that mission very seriously.” 

Get a free test and fast results 

The saliva testing being done at remote sites around the Valley and other parts of Arizona through an ASU and Arizona Department of Health Services partnership is currently free. To preregister and reserve a testing time, go to

Written by Daniel Oberhaus, a staff writer at Wired magazine and the author of “Extraterrestrial Languages” (the MIT Press). An ASU alumnus, ’15 BA in English (creative writing) and philosophy, he is a graduate of Barrett, The Honors College.

Top photo: Clockwise from top left: Biodesign Institute's Building C, ASU's saliva test for COVID-19, Biodesign Institute Director Joshua LaBaer oversees a machine that helps the lab test thousands of samples a day, a test site volunteer scans a participant's appointment QR code, the Biodesign lab expansion, and drive-thru testing. Photos by ASU

image title

On the front lines

September 28, 2020

Meet 6 members of the Sun Devil community who are serving as ASU 'Health Heroes'

Editor's note: This story originally appeared in the fall 2020 issue of ASU Thrive magazine. 

Serving amid the pandemic — as doctors, nurses and professionals — these Sun Devils have one thing in common: strong foundations in expertise, care and compassion, much of which they learned at ASU.

The nurse who goes above and beyond: Erolinda Becerra-Mendoza

For Erolinda Becerra-Mendoza, ’16 BS in nursing and health sciences, staying positive and tending to the emotional care of patients is as much a part of her nursing work as is physical care. “I’ve been working directly with COVID patients,” she said. “Half of the intensive care unit I work in is designated for them, although we are overflowing to our other unit.”

Erolinda Becerra Mendoza

Erolinda Becerra-Mendoza

Although Becerra-Mendoza is a relatively new nurse with four years of experience, she says she’s never seen anything like the challenges that have arisen during the pandemic.  

“I have seen a few success stories in the ICU unit I work in, but I have also seen patients not make it,” she said. “It breaks my heart knowing that they are not surrounded by family during their last hours of life. I love being a nurse, and I try to make this scary time as special as I can for my patients.”

A perfect example? Becerra-Mendoza had a patient who was about to celebrate a birthday. She took the initiative to ensure it was a happy one. 

“A few nurses and I surprised him with a video conference with his family and grandchildren,” she said. “We got him a sugar-free cake and decorated his room. We had to make it special.” And they did. 

The ER doc: Mara Windsor

As an emergency room physician and chief wellness officer, Dr. Mara Windsor, ’98 BS in psychology, faces COVID-19 on a daily basis. Throughout the pandemic, she’s focused on exceptional patient care, as well as ensuring that her colleagues emphasize their own self-care, particularly given the everyday stressors they face.

“I have seen some devastating situations, but I’ve also seen renewed spirit in humanity by people coming together to accept, understand and support each other,” Windsor said. “My nonprofit organization, L.I.F.E. (Living in Fulfilled Enlightenment), has been supporting the front-line heroes by providing personal protective equipment, food and emotional support.”

Most recently, the organization received a donation of 70 backpacks and 70 lunch sacks from the kids’ backpack company MadPax, all of which will be passed along to the children of health care workers as they make their way back to school. 

“It is through our individual diversity that we can come together collectively to meet the needs of our community and society,” Windsor said. “This is the perfect time to create a global movement that will align human compassion with understanding and acceptance of all. I believe that this will result in greater love and compassion for all.” 

The compassionate caregiver: Carmen Dominguez

Carmen Dominguez

As a certified medical assistant for Abrazo Medical Group, Carmen Dominguez, ’19 BS in health care coordination, works at a small clinic, helping to treat a variety of medical issues. While she acknowledges that COVID-19 has presented a lot of new challenges, she’s grateful that her patients can be seen quickly — and without the stress of having to go to the emergency room. 

“Day in and day out, I hear patients telling me they are glad the clinic I’m working at is still open and accepting patients,” she said. “Working mainly with elderly patients, it is not an option to head to the emergency room when they feel heart-related symptoms. We are able to welcome them into a smaller setting than a hospital, (where they are able) to be seen and assessed — and possibly triaged — in-person. We are glad to be here to help and be of service.”

She adds: “I am so proud of my fellow Sun Devils, those working in hospitals, clinics, urgent cares, etc. Everything makes a difference! For those who have yet to graduate, please keep going! We need you.”

The mobile testing innovator: Farah Al Besher

For Farah Al Besher, ’14 BS in economics, who now works as a front-line coordinator with Ambulatory Healthcare Services-SEHA in the United Arab Emirates, early action meant early containment of the virus in her country. 

“I am part of the COVID-19 National Screening Service Drive-Through project in the United Arab Emirates,” Al Besher said. “We were the first to open the drive-thru testing center in the UAE, and due to its success, we were asked to expand our presence by the Crown Prince of Abu Dhabi and Deputy Supreme Commander of the UAE Armed Forces. We were able to build 12 new drive-thru screening centers throughout the seven emirates in 10 days, and today we have 18 fully operational centers. By ensuring early detection of positive cases we have been able to increase the safety of our people.” 

The United Arab Emirates experienced a spike in mid-May, followed by a steady decline in positive cases and a subsequent early July resurgence. Since, though, the country has seen a sustained reduction in COVID-19 cases. 

“Life’s challenges are not supposed to paralyze us,” Al Besher said. “We are all equipped and ready to face any crisis. And remember, you can’t help others without first taking care of yourself. Follow the health guidelines, stay safe and remain positive.”

The mentoring engineer: Aaron Dolgin 

Service and inspiration are just two of the things that motivate Aaron Dolgin, ’18 BS in electrical engineering. Now a systems engineer for Northrop Grumman in Los Angeles, much of Dolgin’s day-to-day life involves a fusion of his love of robotics and systems engineering, and providing for the community. 

Aaron Doglin

Aaron Dolgin

When the pandemic began, Dolgin co-founded a team of more than 150 people who are working to create, print and distribute face shields across Southern California. To date, SoCal Makers COVID-19 Response Team has manufactured and delivered more than 22,000 pieces of personal protective equipment. 

Based on designs and specifications available through the National Institutes of Health, the face shields are 3D-printed visor frames with transparent sheets attached. And many of them are being produced by student volunteers — an extension of Dolgin’s mentorship while he was at ASU. 

“I really enjoyed the robotics program in high school, so I wanted to make sure I gave back in some way,” Dolgin said in June. “During college at ASU, I volunteered at robotics events in Arizona, and I knew I wanted to continue that kind of support when I came back to California. Volunteers don’t need any prior technical knowledge. They may struggle a little at first, but we have a remarkable community ready to get everyone up to speed. All of us are figuring things out together.”

The emergency flight nurse: Christopher Banks

Indeed, compassion is a common theme among alumni health care workers, including Christopher Banks, ’18 BS in nursing, a flight nurse and paramedic for Air EMS Inc. Very early on during the pandemic — in late February — Banks was dispatched to assist in the transport of passengers who had been quarantined aboard the Diamond Princess cruise ship off the coast of Yokohama, Japan. 

“When I reached out my gloved hand, in full PPE, patients couldn’t believe they could touch and shake my hand,” Banks remembers. “This was heart-wrenching.”

Air EMS uses a special isolation unit to safely transport people suffering from COVID-19 that ensures that the paramedic crew and pilots aren’t exposed. It looks like a clear rectangular bubble for patients to lay in on top of the gurney. Banks helped test and train personnel on the isolation unit’s use as the pandemic worsened.

“As a base manager of our air medical transport company, I ensured that all of our care staff safely experienced the confined space of our isolation units to build better compassion for the patients.”

Looking to the future

While a vaccine for COVID-19 remains on the horizon and the world continues to adjust to life in a pandemic, there are a lot of uncertainties. But one thing does seem certain: Current students and researchers, as well as alumni, are working tirelessly — and compassionately — to ensure quality care for a global society. 

To learn more about ASU’s Health Heroes or to submit your story, see

Written by Kelly Vaughn, the senior editor for Arizona Highways. Vaughn, ’04 BA in journalism, has written for many publications including Phoenix magazine and Arrive.

Top photo: (From left) Flight emergency nurse Christopher Banks, ambulatory health care services coordinator Farah Al Besher and emergency room doctor Mara Windsor. Photos by ASU