Discoveries

ASU duo developing sweat patch to check health

Tempe campus Washington, D.C.

August 22, 2016

Project could relay biomarker information to smartphone app, making screenings faster

Karen Anderson is an ASU scientist who sees patients struggle with cancer as she makes rounds as a Mayo Clinic oncologist.

Jennifer Blain Christen is an ASU electrical engineer pushing the boundaries of sensors and circuits to improve health care.

Together, they are combining their expertise to allow people to quickly and inexpensively check their health status.

Anderson, of the Virginia G. Piper Center for Personalized Diagnostics at Arizona State University’s Biodesign Institute, and Blain Christen (pictured at left), of the School of Electrical, Computer, and Energy Engineering in ASU’s Ira A. Fulton Schools of Engineering, are making steady progress on a $1.8 million grant from the Smart and Connected Health Division of the National Science Foundation to make their dream point-of-care technology a reality.

They will create a patch that absorbs sweat to track biological molecules that can indicate the presence of a disease or infection. In their vision, the information could be relayed to a smartphone, making an instant biomarker check easy as step counting or heart rate monitoring on a fitness tracker.

“This technology decreases the burden on health care workers and empowers a person to have a more intimate knowledge of what’s going on in their body,” said Blain Christen. “And what’s in your phone is more powerful than what we had in a big computer just 10 years ago. We don’t have to worry about computation in our patch if we can just get data to this incredible computer now found in everyone’s pockets.”

The technology Anderson and Blain Christen are developing relies on fluorescence detection, used in the biosciences to accurately measure the number of biomarkers present, including those that may predict early detection of cancer, diabetes or infection. The device also uses the latest advances in ASU’s Flexible Display Center technology to customize the fit of the patch, contouring smoothly to a person’s skin, and lowering the overall production costs by packing all of the sensor technology within the patch.

The biggest challenges the scientists have faced in refining their technology include determining which biomarkers are useful to measure in sweat, how to measure molecules present in largely different concentrations and how to make this device accessible to everyone.

“The best tests are only good tests if they can get to people,” Anderson said.

Karen Anderson is an ASU scientist who sees firsthand patient’s struggles with cancer while making rounds as a Mayo Clinic oncologist. Now, she wants to make a difference for people to quickly and inexpensively check their health status.

Anderson and Blain Christen will be using the latest grant funds to confront these challenges, iron out the details of integrating their technology with smartphones, and enhance their first prototype. They predict that the technology will be available for consumers within several years.

Collaboration was essential for establishing the feasibility of creating a point-of-care platform technology and applying for development funding. Anderson and Blain Christen both relied on the help of Ben Katchman, a postdoctoral fellow working with Anderson at the Biodesign Institute, as well as Joseph Smith, a member of the Flexible Electronics and Display Center at ASU.

As Anderson explained, “Part of the reason why I came to the Biodesign Institute, and an exciting part of what we do, is that we get to cross disciplines in ways that are very difficult to do in other institutions. This is something that makes ASU really unique.”

Year in Review: ASU professor leads audiology team to Malawi

audiology grad student looking into patient's ear

Editor's note: This story is being highlighted in ASU Now's year in review. To read more top stories from 2016, click here.Ingrid McBride has just returned from one of the world’s poorest countries, where she spends every summer working to make sure people can hear.McBride, an Arizona State University audiology professor, has traveled to Malawi in southeast Africa for each of the last six ye...

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Global Engagement

ASU professor leads audiology team to Malawi

August 22, 2016

Hearing for Humanity program helps treat hearing loss, train local clinic workers

Editor's note: This story is being highlighted in ASU Now's year in review. To read more top stories from 2016, click here.

Ingrid McBride has just returned from one of the world’s poorest countries, where she spends every summer working to make sure people can hear.

McBride, an Arizona State University audiology professor, has traveled to Malawi in southeast Africa for each of the last six years to address what she calls a “tremendous” need for medical professionals who can help people with hearing problems.

Audiologists provide a range of services, from fitting patients for hearing aids to diagnosing disorders, and there wasn’t a single one in the nation of 16 million people when McBride founded Hearing for Humanity in 2010. “There was just nothing happening as far as ear and hearing care at all,” said McBride, clinical professor and director of the Audiology Clinic at ASU.

Hearing for Humanity seeks to provide care and train local clinicians, implementing sustainable practices that can be put into use long after volunteers leave. McBride’s program also gives ASU students in the Department of Speech and Hearing Science an opportunity to study and work abroad for course credit.

The initiative is fueled by private charitable contributions from individuals and corporate partners. McBride and her team of students work to raise the funds needed to purchase supplies and hearing aids, which they bring with them to Malawi Map of the country of Malawi Malawi is nestled between Mozambique, Tanzania and Zambia. .

Each year, McBride and a team of students — there were 15 in the latest group — spend a month in Malawi, helping curb hearing loss for children and adults at hospitals and clinics across the country.

Since that first year, the level of care in Malawi has improved, though the need is still great. Today, there are still only three audiologists in the nation. But scores of clinic workers have learned from the Hearing for Humanity volunteers, making sure patients have access to care year round.

“Already what’s happened since we’ve been gone is just amazing,” McBride said, adding that people fit with hearing aids have been able to receive follow-up care, “so that makes it sustainable.”

Hearing for Humanity also has helped train four Malawian audiology students selected to attend the University of Manchester tuition-free to obtain master’s degrees. “When they come back, they will be Malawi’s first home-grown audiologists,” McBride said.

group shot of audiology specailists in Malawi

At the end of a long clinic day, the Hearing for Humanity team, along with local interpreters and clinical officers, pose for a group photo in Malawi. Photo courtesy Ingrid McBride

Among the small number of audiologists in Malawi is ASU alum Courtney Caron, who participated in McBride’s program for two years as a student and one year as a professional before setting up her own clinic.

“When I first began graduate school at ASU in 2009,” Caron said, “I had a plan set in my mind: I would graduate with my AuD then pursue an MBA and work my way toward opening my own private practice.”

Instead, she said, she “ended up skipping the MBA” and opening a clinic in a nation where the United Nations reports that 74 percent of the population lives on less than $1.25 a day.

She said she got her own practice in the end, “but I think I was lucky enough to get an opportunity to do it in a much more rewarding way.”

Others involved also say the program has benefits that stretch both ways.

ASU clinical assistant professor Kate Helms-Tillery was a part of McBride’s team this year and said “it’s an important experience for our students” to provide service to others as often as possible. Also, the program gives “students the opportunity to work with people from a different culture,” which she said is “critical because students will also encounter people of different cultures once they begin practicing.”

Audiology graduate student Jessica Wenger (pictured at top) recognized the benefit even before going, saying the program was what "sold" her on attending ASU. “There just aren’t any other universities offering something like it,” she said, calling the opportunity a “huge advantage over the experience you’d get anywhere else.”

For Caron, there is tangible benefit to helping others improve their lives.

“You don’t need to speak the language to understand how much of a difference has been made,” Caron said. “Every task big or small takes so much more effort” in Malawi, “so every progress is a celebration.”

“The effect of any disability on a person’s life here is so much more so than in the U.S.,” she said. “So giving them even the smallest assistance can make a world of difference.”

Top photo courtesy Jessica Wenger.