{"nodes":[{"node":{"nid":"111876","title":"Tracing how cells learned to live without oxygen","body":"Mitochondria are among the most important structures inside living cells. These tiny compartments help generate the energy that powers not only our bodies, but also the cells of all eukaryotes (i.e., animals, plants, fungi and countless single-celled organisms like amoebae).The origin of\u2026","post_date":"\u003Ctime datetime=\u00222026-03-13T09:00:00-07:00\u0022\u003E03\/13\/2026-9:00am\u003C\/time\u003E\n","clas_teaser":"Scientists have discovered unusual microbes that offer new clues about how cells adapt to life with little or no oxygen. The findings help explain how mitochondria, the tiny structures that power our cells, can shrink, change or even disappear over evolutionary time.","teaser":"Mitochondria are among the most important structures inside living cells.","story_images":"","hero_image":"https:\/\/news.asu.edu\/sites\/default\/files\/styles\/block_image_16_9_lge\/public\/2026-03\/mitochondrial-genome-wideman.png?itok=wFzJ8gUg","path":"https:\/\/news.asu.edu\/20260313-science-and-technology-tracing-how-cells-learned-live-without-oxygen","hide_byline":"0","contributor-contact-information-affiliation":"Biodesign Institute at ASU","contributor-contact-information-name":"Richard Harth","contributor-contact-information-e-mail":"{{ mail }}","contributor-contact-information-phone_number":"480-727-0378","contributor-contact-information-campus":"Tempe campus","feed_image_link":"","image_url":"https:\/\/news.asu.edu\/sites\/default\/files\/styles\/block_image_16_9_lge\/public\/2026-03\/mitochondrial-genome-wideman.png?itok=wFzJ8gUg","image_alt":"Graphic illustration of mitochondria","image_caption":"A newly discovered lineage of microbes is helping scientists understand how mitochondria \u2014 the energy-producing structures inside cells \u2014 can evolve, shrink or disappear as organisms adapt to low-oxygen environments. Graphic by Jason Drees\/ASU","related_story":"","news_units":"Biodesign Center for Mechanisms of Evolution|School of Life Sciences|Biodesign Institute|The College of Liberal Arts and Sciences","interests":"Biology|Bioscience|Ecology|Research","audiences":"Faculty","locations":"Tempe campus","u_n_sustainable_development_goals":"","field_feed_herberger":"","field_feed_nursing":"","field_feed_knowledge_enterprise":"Cells","content_type":"asu_news_article","field_saf":"Science and technology"}},{"node":{"nid":"103437","title":"Understanding evolution at the cellular level","body":"By Krista McPhersonNovember 24 is Evolution Day, which commemorates Charles Darwin\u0027s work in evolution. In honor of that, we are featuring Michael Lynch, director of the Biodesign Center for Mechanisms of Evolution, and his work pioneering a new field of research, evolutionary cell biology.\u201c\u2026","post_date":"\u003Ctime datetime=\u00222024-11-20T10:50:07-07:00\u0022\u003E11\/20\/2024-10:50am\u003C\/time\u003E\n","clas_teaser":"Under Michael Lynch\u2019s leadership, the  Biodesign Center for Mechanisms of Evolution is working to change interdisciplinary research, unlocking a new wave of discoveries in a budding sector of science, evolutionary cell biology. ","teaser":"By Krista McPherson","story_images":"","hero_image":"https:\/\/news.asu.edu\/sites\/default\/files\/styles\/block_image_16_9_lge\/public\/2024-11\/lynch_faculty_banner.png?itok=Xe4d3dDv","path":"https:\/\/news.asu.edu\/b\/20241120-understanding-evolution-cellular-level","hide_byline":"1","contributor-contact-information-affiliation":"","contributor-contact-information-name":"","contributor-contact-information-e-mail":"","contributor-contact-information-phone_number":"","contributor-contact-information-campus":"","feed_image_link":"","image_url":"https:\/\/news.asu.edu\/sites\/default\/files\/styles\/block_image_16_9_lge\/public\/2024-11\/lynch_faculty_banner.png?itok=Xe4d3dDv","image_alt":"Portrait of Michael Lynch with scientific texture. ","image_caption":"","related_story":"","news_units":"Biodesign Center for Mechanisms of Evolution|School of Life Sciences|Biodesign Institute|Knowledge Enterprise","interests":"","audiences":"","locations":"","u_n_sustainable_development_goals":"","field_feed_herberger":"","field_feed_nursing":"","field_feed_knowledge_enterprise":"Cells","content_type":"feed_only_article","field_saf":""}},{"node":{"nid":"99265","title":"ASU researchers first to fully sequence Gila monster genome, thanks to crowd-funding campaign","body":"The Sonoran Desert is full of wild creatures, from sharp-tailed scorpions that glow under black light\u0026nbsp;to desert toads that secrete hallucinogenic toxins from their skin. Perhaps no creature, though, is more unique \u2013\u2013\u0026nbsp;or beloved \u2013\u2013 than the venomous and elusive black-and-orange Gila\u2026","post_date":"\u003Ctime datetime=\u00222024-02-28T16:01:51-07:00\u0022\u003E02\/28\/2024-4:01pm\u003C\/time\u003E\n","clas_teaser":"Evolutionary biologist Melissa Wilson and her sex chromosome lab received over $10,000 in crowd-sourced donations to complete the project.","teaser":"The Sonoran Desert is full of wild creatures, from sharp-tailed scorpions that glow under black light\u0026nbsp;to desert toads that secrete hallucinogenic toxins from their skin","story_images":"","hero_image":"https:\/\/news.asu.edu\/sites\/default\/files\/styles\/block_image_16_9_lge\/public\/2024-02\/istock-462078769.jpg?h=6fa590a7\u0026amp;itok=aIvVmm_s","path":"https:\/\/news.asu.edu\/20240306-science-and-technology-asu-researchers-first-fully-sequence-gila-monster-genome-thanks","hide_byline":"0","contributor-contact-information-affiliation":"School of Life Sciences","contributor-contact-information-name":"Risa Aria Schnebly","contributor-contact-information-e-mail":"{{ mail }}","contributor-contact-information-phone_number":"","contributor-contact-information-campus":"Tempe campus","feed_image_link":"","image_url":"https:\/\/news.asu.edu\/sites\/default\/files\/styles\/block_image_16_9_lge\/public\/2024-02\/istock-462078769.jpg?h=6fa590a7\u0026amp;itok=aIvVmm_s","image_alt":"A gila monster is perched next to a cactus with its mouth open.","image_caption":"Only 1.2% of squamates, or scaled reptile species \u2014 such as the Gila monster \u2014 have had their genomes sequenced, compared with 15% of all mammal species, according to Brendan Pinto, who leads the ASU Sex Chromosome Lab\u2019s ongoing research on the Gila monster.\u00a0Photo by kwiktor\/iStock","related_story":"","news_units":"Biodesign Center for Mechanisms of Evolution|School of Life Sciences|Biodesign Institute|Center for Evolution and Medicine|Biosocial Complexity Initiative|The College of Liberal Arts and Sciences|College of Health Solutions","interests":"Biology|Bioscience|Research","audiences":"Faculty|Community","locations":"Tempe campus","u_n_sustainable_development_goals":"","field_feed_herberger":"","field_feed_nursing":"","field_feed_knowledge_enterprise":"Cells","content_type":"asu_news_article","field_saf":"Science and technology"}},{"node":{"nid":"98900","title":"Cheating death: How cancer cells escape ","body":"Cell death is fundamental to life and, thus, healthy aging. In the realm of cellular biology, ferroptosis \u2014 a form of programmed cell death \u2014 has emerged as a focal point of research not only for its potential in eliminating cancer cells, but also its role in a plethora of other diseases, including\u2026","post_date":"\u003Ctime datetime=\u00222024-01-31T09:00:00-07:00\u0022\u003E01\/31\/2024-9:00am\u003C\/time\u003E\n","clas_teaser":"In a groundbreaking study, researchers including ASU\u0026#039;s Judith Klein-Seetharaman have identified a dual role in the intricate dance of cell survival and death, providing key information for future cancer-fighting studies.","teaser":"Cell death is fundamental to life and, thus, healthy aging.","story_images":"","hero_image":"https:\/\/news.asu.edu\/sites\/default\/files\/PaloVerdeBlooms.jpg","path":"https:\/\/news.asu.edu\/20240131-science-and-technology-cheating-death-how-cancer-cells-escape","hide_byline":"0","contributor-contact-information-affiliation":"School of Molecular Sciences","contributor-contact-information-name":"Jenny Green","contributor-contact-information-e-mail":"{{ mail }}","contributor-contact-information-phone_number":"480-965-1430","contributor-contact-information-campus":"Tempe campus","feed_image_link":"","image_url":"https:\/\/news.asu.edu\/sites\/default\/files\/PaloVerdeBlooms.jpg","image_alt":"","image_caption":"","related_story":"","news_units":"School of Molecular Sciences|Biodesign Center for Applied Structural Discovery|Biodesign Institute|The College of Liberal Arts and Sciences|College of Health Solutions","interests":"Bioscience|Undergraduate research|Science|Research","audiences":"Faculty|Graduate students|Staff","locations":"Tempe campus","u_n_sustainable_development_goals":"SDG 03 Good Health and Well-Being|SDG 15 Life on Land","field_feed_herberger":"","field_feed_nursing":"","field_feed_knowledge_enterprise":"TRIF|Cells|Cancer","content_type":"asu_news_article","field_saf":"Science and technology"}},{"node":{"nid":"98941","title":"ASU researchers develop DNA nanodevice for targeted cancer, disease treatment","body":"Sixty years ago, the famous physicist Richard Feynman outlined his vision for the field of nanotechnology in his landmark lecture \u0022There is plenty of room at the bottom.\u0022 Feynman foresaw new exciting applications for nanoscale devices, even conjecturing, \u0022Although it is a very wild idea, it would\u2026","post_date":"\u003Ctime datetime=\u00222024-01-23T09:40:17-07:00\u0022\u003E01\/23\/2024-9:40am\u003C\/time\u003E\n","clas_teaser":"A research team led by ASU Professor Hao Yan has developed a DNA nanodevice that can selectively target cancer cells and deliver specific intracellular treatments.","teaser":"Sixty years ago, the famous physicist Richard Feynman outlined his vision for the field of nanotechnology in his landmark lecture \u0022There is plenty of room at the bottom.\u0022 Feynman foresaw new exciting applications for nanoscale devices, even conjec","story_images":"","hero_image":"https:\/\/news.asu.edu\/sites\/default\/files\/styles\/block_image_16_9_lge\/public\/2024-01\/deep_tissue_penetration_red.png?h=913cc963\u0026amp;itok=i7aCDCt-","path":"https:\/\/news.asu.edu\/20240123-university-news-asu-researchers-develop-dna-nanodevice-targeted-cancer-disease-treatment","hide_byline":"0","contributor-contact-information-affiliation":"School of Molecular Sciences","contributor-contact-information-name":"James Klemaszewski","contributor-contact-information-e-mail":"{{ mail }}","contributor-contact-information-phone_number":"480-965-2729","contributor-contact-information-campus":"Tempe campus","feed_image_link":"","image_url":"https:\/\/news.asu.edu\/sites\/default\/files\/styles\/block_image_16_9_lge\/public\/2024-01\/deep_tissue_penetration_red.png?h=913cc963\u0026amp;itok=i7aCDCt-","image_alt":"Digital image of a nanorobot penetrating tissue cells.","image_caption":"Artist\u0026#039;s conception of a DNA nanorobot designed for targeted, deep penetration into tumor tissue. Graphic by Lu Yu","related_story":"","news_units":"Biodesign Center for Molecular Design and Biomimetics|Core Research Facilities|School of Molecular Sciences|Biodesign Institute|The College of Liberal Arts and Sciences","interests":"Bioscience|Science|Academics|Research","audiences":"Alumni|Faculty|Graduate students|Campus students|Prospective students|Transfer students","locations":"Tempe campus","u_n_sustainable_development_goals":"SDG 03 Good Health and Well-Being|SDG 09 Industry, Innovation and Infrastructure","field_feed_herberger":"","field_feed_nursing":"","field_feed_knowledge_enterprise":"Cells|Cancer|TRIF","content_type":"asu_news_article","field_saf":"Science and technology"}},{"node":{"nid":"97471","title":"ASU study: Mutations in critical gene may steer health outcomes in breast cancer","body":"Despite enormous progress, breast cancer remains elusive, perplexing and, often, deadly. The disease can emerge due to a complex interplay of factors, including lifestyle, environment, aging and genetic predisposition.\n\nIn a groundbreaking new study \u2014 10 years in the making \u2014 co-corresponding\u2026","post_date":"\u003Ctime datetime=\u00222023-10-04T14:27:00-07:00\u0022\u003E10\/04\/2023-2:27pm\u003C\/time\u003E\n","clas_teaser":"In a groundbreaking new study \u2014\u00a010 years in the making \u2014 co-corresponding authors Joshua LaBaer and Jin Park, along with their Arizona State University colleagues, found that certain mutations in a gene known as TP53 can dramatically alter the aggressiveness of cancer-related characteristics.","teaser":"Despite enormous progress, breast cancer remains elusive, perplexing and, often, deadly. The disease can emerge due to a complex interplay of factors, including lifestyle, environment, aging and genetic predisposition.","story_images":"","hero_image":"https:\/\/news.asu.edu\/sites\/default\/files\/styles\/block_image_16_9_lge\/public\/tumor_cells.png?itok=wsKuo_H5","path":"https:\/\/news.asu.edu\/20231004-asu-study-mutations-critical-gene-may-steer-health-outcomes-breast-cancer","hide_byline":"0","contributor-contact-information-affiliation":"Biodesign Institute at ASU","contributor-contact-information-name":"Richard Harth","contributor-contact-information-e-mail":"{{ mail }}","contributor-contact-information-phone_number":"480-727-0378","contributor-contact-information-campus":"Tempe campus","feed_image_link":"","image_url":"https:\/\/news.asu.edu\/sites\/default\/files\/styles\/block_image_16_9_lge\/public\/tumor_cells.png?itok=wsKuo_H5","image_alt":"Close-up illustration of tumor cells.","image_caption":"Illustration of tumor cells. A new study examines mutations in the cancer suppressor gene TP53, which can lead to an aggressive, treatment-resistant disease known as triple-negative breast cancer. Graphic by Jason Drees","related_story":"","news_units":"Biodesign Virginia G. Piper Center for Personalized Diagnostics|School of Molecular Sciences|Biodesign Institute","interests":"Bioscience|Health care|Research","audiences":"Faculty","locations":"Tempe campus","u_n_sustainable_development_goals":"SDG 03 Good Health and Well-Being","field_feed_herberger":"","field_feed_nursing":"","field_feed_knowledge_enterprise":"TRIF|Cells|Cancer","content_type":"news","field_saf":"Science and technology"}},{"node":{"nid":"96887","title":"ASU study: Artificial cells demonstrate life\u0027s remarkable adaptability","body":"A single cell is a condensed universe, containing a rich storehouse of genetic information necessary for survival and reproduction. But how essential are all those genes, and could a cell manage to flourish and evolve without so much complexity?\n\nIn new research, Michael Lynch, director of the\u2026","post_date":"\u003Ctime datetime=\u00222023-07-14T13:03:00-07:00\u0022\u003E07\/14\/2023-1:03pm\u003C\/time\u003E\n","clas_teaser":"An ASU research team found that a streamlined cell can evolve just as fast as a normal cell, demonstrating the capacity for organisms to adapt \u2014 even with an unnatural genome that would seemingly provide little flexibility. Despite their radically simplified state, the cells displayed a robust capacity to evolve, regaining 80% of their biological fitness in around 2,000 generations.","teaser":"A single cell is a condensed universe, containing a rich storehouse of genetic information necessary for survival and reproduction.","story_images":"","hero_image":"https:\/\/news.asu.edu\/sites\/default\/files\/styles\/block_image_16_9_lge\/public\/lynch_synthetic_genome_asunews.png?itok=q2DC2c2D","path":"https:\/\/news.asu.edu\/20230714-asu-study-artificial-cells-demonstrate-lifes-remarkable-adaptability","hide_byline":"0","contributor-contact-information-affiliation":"Biodesign Institute at ASU","contributor-contact-information-name":"Richard Harth","contributor-contact-information-e-mail":"{{ mail }}","contributor-contact-information-phone_number":"480-727-0378","contributor-contact-information-campus":"Tempe campus","feed_image_link":"","image_url":"https:\/\/news.asu.edu\/sites\/default\/files\/styles\/block_image_16_9_lge\/public\/lynch_synthetic_genome_asunews.png?itok=q2DC2c2D","image_alt":"Graphic illustration of a genome.","image_caption":"In the study, a synthetically constructed minimal cell, derived from the bacterium M. mycoides, was reduced to a suite of essential genes. The researchers describe the functioning of a stripped-down version of this bacterial cell and its startling ability to overcome the paucity of its modified genome. Graphic by Jason Drees","related_story":"","news_units":"Biodesign Institute","interests":"Bioscience|Research","audiences":"Faculty","locations":"Tempe campus","u_n_sustainable_development_goals":"","field_feed_herberger":"","field_feed_nursing":"","field_feed_knowledge_enterprise":"TRIF|Cells","content_type":"news","field_saf":"Science and technology"}},{"node":{"nid":"96281","title":"Research illuminates \u0027programmed cell death\u0027 process induced by a common toxin","body":"Cells are the building blocks of our body and many other organisms. But did you know that sometimes cells need to die? This might sound surprising but is actually a very important process, called \u0022cell suicide\u0022 or \u0022programmed cell death,\u0022 for an organism to work properly. Arizona State University\u2026","post_date":"\u003Ctime datetime=\u00222023-05-01T18:59:00-07:00\u0022\u003E05\/01\/2023-6:59pm\u003C\/time\u003E\n","clas_teaser":"Professor Bertram Jacobs from ASU\u0026#039;s School of Life Sciences recently published an article in the journal Science Signaling that provides new insight into the mechanism that leads to programmed cell death after arsenite exposure. ","teaser":"Cells are the building blocks of our body and many other organisms. But did you know that sometimes cells need to die? ","story_images":"","hero_image":"https:\/\/news.asu.edu\/sites\/default\/files\/styles\/block_image_16_9_lge\/public\/bertsimage_zbp1.png?itok=-tph8S2d","path":"https:\/\/news.asu.edu\/20230501-common-chemical-has-viruslike-response-induces-cell-death","hide_byline":"0","contributor-contact-information-affiliation":"School of Life Sciences","contributor-contact-information-name":"Anaissa Ruiz-Tejada","contributor-contact-information-e-mail":"{{ mail }}","contributor-contact-information-phone_number":"","contributor-contact-information-campus":"Tempe campus","feed_image_link":"","image_url":"https:\/\/news.asu.edu\/sites\/default\/files\/styles\/block_image_16_9_lge\/public\/bertsimage_zbp1.png?itok=-tph8S2d","image_alt":"Image showing cells and how ZBP1 localizes to stress granules during arsenite-induced necroptosis.","image_caption":"Cells that show how ZBP1 localizes to stress granules during arsenite-induced necroptosis. Photo courtesy Bertram Jacobs","related_story":"","news_units":"Biodesign Center for Immunotherapy, Vaccines and Virotherapy|School of Life Sciences|Biodesign Institute|Center for Evolution and Medicine|The College of Liberal Arts and Sciences","interests":"Biology|Bioscience|Life Science","audiences":"Faculty|Graduate students","locations":"Tempe campus","u_n_sustainable_development_goals":"","field_feed_herberger":"","field_feed_nursing":"","field_feed_knowledge_enterprise":"Cells","content_type":"news","field_saf":"Science and technology"}},{"node":{"nid":"96049","title":"Circular DNA takes center stage in a deadly form of cancer, research shows","body":"A circular form of DNA, known as extrachromosomal DNA, often contains genes that can turbocharge the development of cancer while dampening the immune system\u2019s capacity to cope with the assault.A new study examines the role of extrachromosomal DNA in the development of esophageal adenocarcinoma, or\u2026","post_date":"\u003Ctime datetime=\u00222023-04-18T11:56:00-07:00\u0022\u003E04\/18\/2023-11:56am\u003C\/time\u003E\n","clas_teaser":"An ASU researcher is among the team that investigated extrachromosomal DNA, finding it often contains genes that can turbocharge the development of cancer while dampening the immune system\u2019s capacity to cope with the assault.","teaser":"A circular form of DNA, known as extrachromosomal DNA, often contains genes that can turbocharge the development of cancer while dampening the immune system\u2019s capacity to cope with the assault.","story_images":"","hero_image":"https:\/\/news.asu.edu\/sites\/default\/files\/styles\/block_image_16_9_lge\/public\/barretsesophagusextrachromosomal.png?itok=tColPvcl","path":"https:\/\/news.asu.edu\/20230418-circular-dna-takes-center-stage-deadly-form-cancer","hide_byline":"0","contributor-contact-information-affiliation":"Biodesign Institute at ASU","contributor-contact-information-name":"Richard Harth","contributor-contact-information-e-mail":"{{ mail }}","contributor-contact-information-phone_number":"480-727-0378","contributor-contact-information-campus":"Tempe campus","feed_image_link":"","image_url":"https:\/\/news.asu.edu\/sites\/default\/files\/styles\/block_image_16_9_lge\/public\/barretsesophagusextrachromosomal.png?itok=tColPvcl","image_alt":"Graphic illustration showing a case of Barrett\u0026#039;s esophagus within a person.","image_caption":"Barrett\u0026#039;s esophagus occurs when the normal squamous lining of the esophagus is replaced with columnar tissue, which is more resistant to the damaging effects of stomach acid. Those with the condition have a higher risk for developing a highly lethal cancer known as esophageal adenocarcinoma. Graphic by Jason Drees","related_story":"","news_units":"Biodesign Center for Biocomputing, Security and Society|School of Life Sciences|Biodesign Institute","interests":"Bioscience","audiences":"Community","locations":"Tempe campus","u_n_sustainable_development_goals":"","field_feed_herberger":"","field_feed_nursing":"","field_feed_knowledge_enterprise":"TRIF|Cancer|Cells","content_type":"news","field_saf":"Science and technology"}},{"node":{"nid":"95116","title":"Compounds found in plants offer new hope in the fight against prostate cancer","body":"Prostate cancer has a high prevalence among men, second only to skin cancer. It is estimated that one in eight men will be diagnosed with the disease in their lifetime.In a new study, Raimund Fromme at Arizona State University\u2019s Biodesign Institute Center for Applied Structural Discovery joins\u2026","post_date":"\u003Ctime datetime=\u00222023-01-27T17:21:00-07:00\u0022\u003E01\/27\/2023-5:21pm\u003C\/time\u003E\n","clas_teaser":"In a new study, Raimund Fromme at Arizona State University\u2019s Biodesign Institute Center for Applied Structural Discovery joins researchers Eli Chapman and Leslie Gunatilaka from the University of Arizona to explore a potent plant compound that could inhibit prostate cancer.","teaser":"Prostate cancer has a high prevalence among men, second only to skin cancer. It is estimated that one in eight men will be diagnosed with the disease in their lifetime.","story_images":"","hero_image":"https:\/\/news.asu.edu\/sites\/default\/files\/styles\/block_image_16_9_lge\/public\/raimond-fromme-physachenolide-c-inhibitor2_0.png?itok=xKLWTKHl","path":"https:\/\/news.asu.edu\/20230127-compounds-found-plants-offer-new-hope-fight-against-prostate-cancer","hide_byline":"0","contributor-contact-information-affiliation":"Biodesign Institute at ASU","contributor-contact-information-name":"Richard Harth","contributor-contact-information-e-mail":"{{ mail }}","contributor-contact-information-phone_number":"480-727-0378","contributor-contact-information-campus":"Tempe campus","feed_image_link":"","image_url":"https:\/\/news.asu.edu\/sites\/default\/files\/styles\/block_image_16_9_lge\/public\/raimond-fromme-physachenolide-c-inhibitor2_0.png?itok=xKLWTKHl","image_alt":"","image_caption":"Withanolide compounds, which occur naturally in some plants, act by inhibiting an important class of cancer-linked proteins, known as BET proteins. One potent inhibitor, known as PCC, is pictured in this illustration. The PCC structure was characterized in a new study using X-ray crystallography and NMR imaging. Graphic by Jason Drees","related_story":"","news_units":"School of Molecular Sciences|Biodesign Center for Applied Structural Discovery|Biodesign Institute|The College of Liberal Arts and Sciences","interests":"Bioscience|Health care|Science|Research","audiences":"Faculty","locations":"Tempe campus","u_n_sustainable_development_goals":"","field_feed_herberger":"","field_feed_nursing":"","field_feed_knowledge_enterprise":"TRIF|Cancer|Cells","content_type":"news","field_saf":"Science and technology"}}]}