Technology training for teacher candidates earns national award

July 17, 2012

A team from ASU’s Mary Lou Fulton Teachers College has earned national honors for a research paper describing the college’s evolving approach to teaching technology skills to future teachers.

The International Society of Technology in Education (ISTE) presented its SIGTE (Special Interest Group of Teacher Educators) Research Paper Award to Teachers College faculty members Teresa S. Foulger, Keith Wetzel and Ray Buss, and academic professional LeeAnn Lindsey, for “Preservice Teacher Education: Benchmarking a Stand-Alone Ed Tech Course in Preparation for Change.” The award was presented at the annual ISTE conference in San Diego in June. Teresa Foulger, Keith Wetzel, Ray Buss and LeeAnn Lindsey Download Full Image

The topic for the “Preservice Teacher Education” paper originated from the major curriculum redesign process under way in Teachers College. Among the changes being implemented in the new iTeachAZ curriculum is the elimination of a stand-alone course focusing on the use of technology in PreK-12 classrooms. Instead, technology is infused into a group of content methods courses for teacher candidates.

“The paper benchmarks the best practices from the stand-alone educational technology course that we don’t want to lose as the college moves towards an integrated, programmatic approach,” Foulger said. “Educational technology faculty were charged with leading the process. Our first step was to conduct this benchmarking study of the stand-alone course to determine the best practices that could be incorporated into the new program design.”

“Technologies seem to saturate our lives, but their purposeful use in K-12 teacher preparation classrooms sometimes eludes us,” Wetzel said.

“In Teachers College we strive to prepare K-12 teachers to integrate technology appropriately in their future classrooms, not just take children to the computer lab several periods a week,” he said. “The redesign of the teacher certification curriculum allows us to model and practice technology use in all of our methods courses. This study explains the promise of the new approach and sets the benchmarks for comparing the standalone course to the new approach.”

Results from quantitative and qualitative data in the study indicated students’ confidence and Technological Pedagogical Content Knowledge (TPACK) scores increased in the stand-alone course. TPACK is a framework to understand and describe the kinds of knowledge needed by a teacher for effective pedagogical practice in a technology-enhanced learning environment.

Benchmarks that arose from the study included those associated with computer skill development and TPACK development. The authors will share those benchmarks with program developers for adoption or adaptation where appropriate.

ASU’s Mary Lou Fulton Teachers College offers challenging education programs that prepare highly qualified and successful teachers, leaders, and researchers. Teachers College serves all four ASU campuses in metropolitan Phoenix and students across Arizona.

Evolutionary information improves genomic medicine

July 17, 2012

A book containing misprints may cause annoyance for the reader, but typos in an individual’s genetic blueprint (DNA) can mean serious disease or even death. The search for genetic correlates for the wide range of diseases plaguing humankind has inspired a wealth of research falling under the heading of genome-wide association studies (GWAS). 

According to Sudhir Kumar, director of the Center for Evolutionary Medicine and Informatics at Arizona State University’s Biodesign Institute, however, results from many such studies become less useful when gene variants or alleles implicated in disease in a given population fail to be discovered in subsequent independent studies. “Often, we do not discover the same set of mutations for the same disease in different populations,” he says. “This is a huge problem in genomic medicine.” Download Full Image

Kumar and colleagues Joel T. Dudley, Rong Chen, Maxwell Sanderford, and Atul J. Butte, have developed a statistical method to remedy this problem by using evolutionary information. It is capable of significantly enhancing the likelihood of identifying disease-associated alleles that show better consistency across populations, improving the reliability of GWAS studies. The method makes use of phylogenetics – the comparative study of species genomes through long-term evolutionary history.

The group’s research appeared in the advanced online issue of the journal Molecular Biology and Evolution. The new method is now available to use via the web, so that researchers worldwide can apply it as an aid to discovering disease-associated mutations that are more consistently reproducible and therefore useable as diagnostic markers. Kumar refers to this new approach, combining standard comparative genomic studies with phylogenetic data as phylomedicine, a rapidly developing field that promises to streamline genomic information and improve its diagnostic power.

“We can take this method and apply it to all the data that has been published,” Kumar says. “It will lead to new discoveries that were sitting right there, but nobody knew about.”

The new method boosts the discovery of reproducible mutations by integrating evolutionary history of humans with contemporary genomic information. Applying the new rankings to a large GWAS study improved the discovery of reliable mutation correlates of complex diseases, which will advance personalized medicine based on each patient’s genomic code.

The basic idea behind GWAS is simple: compare the genomes of two populations of subjects, one with disease trait and a control group without the disease. Next, identify the disparities at each position of the genome in the two populations. Find the alleles occurring in the diseased population that are less frequent in the healthy population and you have just pinpointed the gene mutations associated with disease.

Or have you?

As Kumar explains, matters are not so simple. The mutations studied in such studies are known as SNPs (for single-nucleotide polymorphisms). This simply means that for a given gene sequence, one of the four nucleotides (A,T,C and  G) found commonly in the population is replaced by something else. For example, the majority of healthy subjects may carry the ‘A’ at a particular position in the genome, but disease individuals may be more likely to carry a ‘C’ at the same position. If the difference between the groups is striking, the SNP may be associated with the disease trait.

Human genomes are vast structures – consisting of some 3 billion base pairs of nucleotides. Most are littered with SNPs and teasing out which ones sit there without apparent effect and which may translate to disease is often a vexing affair. For some diseases, a one-to-one correspondence between gene mutation and disease exists. Generally, these afflictions, known as monogenic diseases, have particular characteristics. They result from a mutation in just a single gene, rather than multiple genes. They are early-onset diseases, taking their toll when the patient is still young.

Monogenic diseases, which include cystic fibrosis, Tay sachs disease, sickle cell anemia and Huntington’s disease are usually not the targets for genome-wide association studies, because the relationship between gene mutation and occurrence of the disease is straightforward and reliable.

By contrast, so-called complex diseases tend to occur later in life, are triggered by mutations occurring at multiple sites along the genome and often have a significant environmental– that is, non-genetic – component. Finding the alleles responsible for such diseases, which include hypertension, rheumatoid arthritis, Alzheimer’s disease, type II diabetes and countless others through GWAS studies has often been a bewildering endeavor, as alleles identified in one study population frequently fail to turn up in different studies with different populations.

GWAS studies compute the odds of an allele along the genome being disease-related and translate this into a statistic known as the P value. Alleles with the lowest P value are least likely to have occurred by random chance. In the current research, a meta-analysis is conducted using results from thousands of previous GWAS studies and phylogenetics are applied to unearth evolutionary trends in the data.

“Every position in the human genome among the billions of base pairs has evolved over time,” Kumar says. “As the genome evolves, some positions permit change frequently while others do not.” The positions least likely to change with time and across mammalian species are known as evolutionarily conserved positions. The group conducted a multispecies genomic analysis of 5,831 putative human risk variants for more than 230 disease phenotypes reported in 2,021 studies. “Even if a GWAS variant does not have a functional role in a disease, evolutionary information is still very relevant, because every position in the human genome has an evolutionary signature that gives us prior information on how alleles at that position are likely to vary in modern human populations,” says Dudley, the study’s lead author.

An analysis of existing data found that most of the presumptively disease-related alleles uncovered in the GWAS studies occurred at relatively slow-evolving, highly conserved sites. According to Kumar, this fact accounts for the poor reproducibility of many putative disease alleles across different populations, as alleles occurring at conserved sites tend to be rare. As Kumar explains “You can keep finding rare alleles like this all day, but they would have limited clinical utility in a broader population.”

The new ranking system, known as E-ranking, incorporates phylogenetic information from multi-species studies of mammals, and applies it to human GWAS data. The effect is to remove the inherent sampling bias for rare alleles, allowing the more common alleles occurring at fast-evolving sites in the genome to be more readily discovered. “Our method removes this bias, which gives a boost to high-frequency common variants that are more likely to reproduce across populations due to the evolutionary history of the genomic position where they are found,” says Dudley.

Richard Harth

Science writer, Biodesign Institute at ASU