Psychology Dean's Medalist aims to help teens recognize digital domestic violence

Annie Cooper conducts research to help teens and their families

November 28, 2022
Editor’s note: This story is part of a series of profiles of notable fall 2022 graduates.

Senior psychology student Annie Cooper came to Arizona State University as a transfer student from community college and immediately immersed herself in as many opportunities as possible.

She joined the Psi Chi Honors Society as the director of their social media accounts and found herself realizing that she could be the next president.  Annie Cooper Annie Cooper is a senior psychology student who is graduating this December Download Full Image

“I thought, why not give it a shot?” Cooper said. 

Now, not only is she president of Psi Chi, but she conducts research as part of three labs — the Heart Lab with Associate Professor Thao Ha, the Behavioral Alcohol Research for Clinical Advancement Lab with Professor William Corbin and the Memory and Attention Control Lab with Associate Professor Gene Brewer

Cooper, who is graduating this December, has been named the Dean's Medalist for the fall semester in the Department of Pyschology.

After graduating, Cooper intends on going to graduate school for behavioral neuroscience and hopes to continue conducting research on relationships, mental health and addiction. 

“Each of the labs that I am a part of conduct important research on various parts of the human experience and I’m looking forward to growing more as a researcher in a graduate program,” Cooper said. 

While conducting research, she also launched her own full-service marketing company to promote nutritional supplements through strategic social media and influencer marketing. This social media marketing background gave her an insider’s look into her honors project with the Heart Lab. 

“For me, I enjoyed marketing, but it's not something I saw myself doing in the long term. I wanted a career that felt purposeful and I didn't really think marketing could give me that. Once I started getting involved with research, I found that it's something that really excites me,” she said.

Cooper joined the Heart Lab two years ago while she was volunteering at a Title I high school in Phoenix. She noticed that many of the girls had been through difficult experiences, including many unhealthy relationships with partners, parents, family and friends. 

“I was interested in how those affected the students long term, even just after seeing them in the classroom and things they were struggling with. It was more than anything I'd ever seen at other public schools,” Cooper said.

This experience translated to her research in the Heart Lab.

According to a national survey of high school students, more than 28% had experienced digital dating abuse in the past year with 32% of male students and 24% of female students reporting having experienced it. Among students with dating experience, 76% reported either using or experiencing at least one digital dating abuse behavior in their lifetime and 59% reported both using and receiving digital dating abuse behavior. 

“Right now we're looking at parental mediation, a strategy used by parents to monitor and regulate their child's media use and digital dating abuse. We're seeing if the two relate to one another – if parental mediation makes parents more aware of digital dating abuse. A lot of parents aren't aware that this is such a problem,” Cooper said.

“The problem with digital dating abuse is that it lacks the boundaries of in-person abuse. This means it is a lot easier to have this consistently happen to you if you're in a relationship like that. We're looking at this research to see if parents are aware of digital dating warning signs so we can hopefully come up with good interventions in the future,” she said.

Cooper’s independent project highlights the importance of parental involvement in adolescent relationships. 

“Annie is one of those students who is always willing to step up, and she shows great initiative in research. Her independent research project with fellow student Shane Kasmarogi is an excellent example of how she can turn something she is interested in into a research project,” said Ha, the lead researcher at the Heart Lab. 

In addition to her work in the Heart Lab, she is conducting research on trauma and its impact on cognition with the Memory and Attention Control lab.  

“We're trying to look at trauma and cognition and see how people with the highest 20% ratings of trauma perform on these cognitive assessments versus the people who don't,” Cooper said. “This includes developmental trauma as well as more acute trauma, like a traumatic brain injury.”

Cooper is also a research assistant in the Behavioral Alcohol Research for Clinical Advancement Lab lab where she is conducting a literature review for internalizing disorders such as anxiety and depression and coping models with substance use. 

“My interest lies in the treatment of all of these issues. I'm interested in the treatment of anxiety, depression, post-traumatic stress disorder and substance misuse. For instance, even though we categorize them differently, someone with anxiety or depression might have PTSD as well because they've experienced trauma in the past, and they might self-medicate with some substances,” Cooper said. 

Robert Ewing

Marketing and Communications Manager, Department of Psychology


Wild primate study ties importance of social environment to molecular markers of age in the brain

November 28, 2022

As people age, maintaining a positive and predictable social environment becomes more and more important. For instance, keeping close ties with friends and family has been identified as one of the key ingredients to healthy aging. 

While some declines in health, mind and body are inevitable, studies have shown that maintaining a positive social environment can help stave off some of the key stressors and challenges of aging. An older female macaque monkey. New research findings provide a rich molecular resource cataloging of age-associated molecular changes in the brain, based off a model nonhuman primate living in a complex social and naturalistic environment. Photo courtesy Amanda Melin/University of Calgary Download Full Image

Scientists have long been interested in exploring these root causes and studying how the environment might provide a route to slow down the pace at which our brains age.

“We still don’t have a good handle on how our social environment can ‘get under the skin’ to affect our bodies and brains, but a lot of recent work has pointed to changes at the level of gene regulation — how our genes are turned on and off,” said Noah Snyder-Mackler, an assistant professor at Arizona State University’s School of Life Sciences and Center for Evolution and Medicine and affiliate of the Neurodegenerative Disease Research Center at ASU’s Biodesign Institute. 

With new technologies available, scientists can begin to tease out the mysterious connection between the dynamics of one’s social environment and molecular changes in the brain.

But with human studies difficult to perform and aging processes protracted over decades of the typical human life span, scientists like Snyder-Mackler have turned to using our closest genetic cousins, nonhuman primates, to better understand how our social environment can alter our physiology — from the organismal level all the way down to our genes.

In a new study, Snyder-Mackler and co-first authors Kenneth Chiou (a postdoctoral researcher at ASU) and Alex DeCasien (formerly at New York University, now a postdoctoral researcher at the National Institute of Mental Health) led an international research team that demonstrated that, in a population of macaque monkeys, females with a higher social status had younger, more resilient molecular profiles, providing a key link between the social environment and healthy brains.

This work was conducted in rhesus macaques, which “are the best-studied nonhuman primate model species in medicine. These animals also show some of the same age-related changes that we see in humans, including declines in bone density and muscle mass, immune system changes, and an overall impairment of behavioral, sensory and cognitive function,” said Snyder-Mackler.

Headshot of Nick Snyder-Mackler, assistant professor at ASU

ASU Assistant Professor Noah Snyder-Mackler

The team included key collaborators at the Caribbean Primate Research Center at the University of Puerto Rico, University of Washington, University of Pennsylvania, University of Exeter, New York University, North Carolina Central University, University of Calgary and University of Lyon. The study was published in the journal Nature Neuroscience and funded by the National Institute on Aging, National Institute of Mental Health, National Science Foundation and the National Institutes of Health Office of Research Infrastructure Programs.

“This study builds upon more than 15 years of work by our team investigating the interactions between social behavior, genetics and the brain in the Cayo macaques,” said Michael Platt, a professor in the Perelman School of Medicine, School of Arts and Sciences and Wharton Business School at the University of Pennsylvania. “The discoveries made by our team demonstrate the value of all the hard work and resources invested in this long-term study.” 

“The study shows the value in building long-term collaborative networks across institutions,” added James Higham, a professor of anthropology at New York University. “Long-term funding for such networks is the key to enabling important multidisciplinary findings in naturalistic animal populations.” 

The social environment and biology of aging

A broad theme of Snyder-Mackler’s lab is to investigate the root causes and consequences of variation in the social environment, examined at scales from tiny molecules all the way to the whole organism.

In the past decade, new genomic technologies have propelled researchers to probe these interactions at an unprecedented level to explore this dynamic interaction between the environment and the genome. Can a social or environmental adversity mimic older age at the molecular level?  The answer is a decided yes. Snyder-Mackler’s team recently published one of the first studies showing that individuals who experienced a natural disaster, specifically a hurricane, had molecularly older immune systems.

The group they have studied is a population of free-ranging rhesus macaques living on the isolated island of Cayo Santiago, Puerto Rico. The animals have lived on the island since 1938 and are managed by the Caribbean Primate Research Center.

To make the connections between social status and the inner workings of the brain, the team undertook two complimentary studies: 1) generating comprehensive gene expression datasets from 15 different regions of the brain, and 2) focusing on one region in greater detail at the single-cell level (in this case, a detailed analysis within a single region of the brain, the dorsolateral prefrontal cortex (dlPFC), a brain area long associated with memory, planning and decision-making). This work was complemented by detailed behavioral observations and data collection on 36 study animals (20 female and 16 male). 

Emergent patterns

When they grouped each sample brain region by age, eight distinct clusters of genes stood out. Among the most interesting were those involved in metabolic processes, cell signaling, and the immune and stress responses. 

“We ended up identifying thousands of genes showing age-associated differences in expression patterns, including roughly 1,000 that show highly consistent patterns across the brain,” said Chiou.

Next, they homed in on their analysis to magnify the prefrontal cortex area of the brain at a single-cell level.

“We complemented our brain-wide gene expression data with measures of the expression of genes in 71,863 individual cells in the dlPFC across in 24 females spanning the macaque life span,” said Chiou.  

The gene expression data allowed them to classify each individual cell into eight broad neural cell types (e.g., excitatory neurons, microglia, etc.) and then further parse them into 26 distinct cell types and sub­types in the dlPFC brain region.

They also revealed strong parallels between macaque and human gene expression signatures of age. Some of this variation was specific to regions associated with degenerative neurological diseases, while others reflect conserved neurological patterns associated with older age across the whole brain.

When compared to the mouse and human brain data, the pathways showing the greatest similarities in variation linked to age across regions were central to brain cell-to-cell communication (chemical synaptic transmission, shared across five regions), brain growth (negative regulation of neurogenesis, shared among three regions), and a key brain regulatory gene for cell growth and death (positive regulation of the proinflammatory cytokine tumor necrosis factor, shared across three regions).

But not all the findings found parallels in humans, suggesting that there may be root causes of some neurodegenerative disease that are also part of what make us uniquely human.

These key differences between the effects of age in macaques and humans could help explain the unique mechanisms underlying some human neurodegenerative diseases.

Among the biochemical pathways show­ing the greatest age divergence across regions were energy pathways (electron trans­port chain/oxidative phosphorylation, found in four regions). Interestingly, human neurodegenerative diseases, such as Parkinson’s disease (four regions), Huntington’s disease (three regions) and Alzheimer’s (one region), were associated with some of the most diverged gene sets between humans and monkeys.

“This suggests that, while neurodegeneration path­ways in humans differ from macaques in their age profiles in some regions, they still exhibit strong overlap with social adversity, paralleling epidemiological links in humans between social adversity and neurodegenerative diseases,” said DeCasien.

Aging is associated with variation in the social environment

Next, the team applied their data to the social aspects of macaque aging, which have several unique features. In female macaques, dominance rank (the monkey analog of social status) is inherited from their mother and, for the most part, remains stable throughout their lives. This is very different from the pattern found in male macaques, who leave their groups when they mature and enter their new groups at the bottom of the hierarchy before rising in rank as their tenure in the new group lengthens.

“Evidence in humans and other social species suggests that variability in the risk, onset and progression of age­-related morbidities is explained in part by variation in social adversity,” said Snyder-Mackler. “In female macaques, for instance, low social status is associated with increased mortality, and its effects on immune cell gene expression is similar to gene expression signatures of aging in humans.”

From there, they wanted to determine whether social adversity could be linked with molecular signatures of age in the macaque brain. They found that the effect of rank on gene expression was particularly driven by younger molecular profiles in high-­ranking females, suggesting that associations between higher rank and younger brain age are not expressed linearly along the social hierarchy but instead are specific to females with the highest ranks. High social status may confer several advantages, including increased access to resources, more predictable environ­ments and decreased harassment from groupmates.

“Our findings provide some of the first evidence of molecular parallels between aging and social adversity in the brain — providing a key mechanism linking adverse (or conversely, beneficial) environments and earlier onset and faster progression of age-related brain decline and disease,” said DeCasien.

Final thoughts

These atlases and findings will now provide valuable targets for future studies in a tractable, clinically important model of human health and aging. 

These links potentially have a causal explanation; the chronic stress of social adversity, for instance, has been proposed to acceler­ate aging by promoting chronic inflammation from a weakened immune system. Their work underscores the importance of considering the social environment as a key modifier of aging and health.

“There is no longer any doubt that the social lives of humans and other group-living animals are inexorably intertwined with the rest of their biology,” say Lauren Brent, an associate professor of psychology and animal behavior at the University of Exeter. “Exciting future research will show us why our interactions with others might impact how quickly we age, and whether these impacts are reversible."

“Taken together, our findings provide a rich molecular resource cataloging age-associated molecular changes in the brain – in a model nonhuman primate living in a complex social and naturalistic environment,” said Snyder-Mackler. “We hope they will lend new insights into how we can all lead longer, healthier and happier lives.”

Joe Caspermeyer

Manager (natural sciences), Media Relations & Strategic Communications