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College broadcasters warm up at Cape Cod Baseball League

5 ASU journalism students earn internships with Cape Cod League this summer.
Many of baseball's top stars played in the Cape Cod League on their way up.
July 5, 2016

Amateur league showcases talented players before they make it big — both behind the plate and behind the mic

There is an iconic simplicity to the Cape Cod Baseball League: Fans bring folding chairs and coolers, ballpark tickets are free, food selections are limited, and they don’t sell beer.

The more seasoned spectators relax as they watch the young men play, and scouts hidden in the stands or near the press box diligently take notes and check stopwatches. Both groups hope to glimpse a future star before he becomes famous.

More than 1,000 league veterans have gone on to Major League Baseball, and you may have heard of some of them: Tim Lincecum, Jacoby Ellsbury, Buster Posey, Barry Zito and Nomar Garciaparra, just to name a few.

For the student broadcasters at the Massachusetts league, this is also their time to hone their skills on their way to making it big. Five students from Arizona State University's Walter Cronkite School of Journalism and Mass Communication scored internships with the league this year, the most of any university represented at the Cape for the second year in a row. Just like the players on the field, they had to prove themselves to earn their spot.

André Simms is the on-field reporter for the Wareham Gatemen. He also steps in as the play-by-play announcer and sometimes does color commentary, filling in the gap between plays with interesting information about teams and players, the overwhelming majority of whom are NCAA student-athletes keeping sharp over the summer.

“It’s a lot of work, but it’s so rewarding,” he said of his time at the Cape League. Since he landed the internship in January, he has been preparing for the job by doing research and keeping tabs on the players.

Cronkite School broadcast student Andre Simms works a game at the Cape Cod Baseball League.

Emerging broadcasters work on their skills during a game at the Cape Cod Baseball League. For the second year in a row, the Walter Cronkite School of Journalism and Mass Communication had the most students of any college represented. Photo by Logan Clark/ASU

Simms is a rising junior who attended St. Mary’s College High School in Berkeley, California, and was attracted to Cronkite by the professionalism, state-of-the-art equipment and myriad opportunities to put his training to good use.

The students gave props to the Cronkite School for helping them prepare to be competitive and successful in sports journalism.

“In two years, I’ve been able to grow so much as a journalist and improve tenfold since I got on campus,” Simms said. “I’m getting these real-world opportunities, like coming out here on the Cape. I’ve worked for ESPN, the Pac-12 Networks, and that’s not something other schools are going to offer right away.”

He also credited ASU’s emphasis on inter- and multi-disciplinary learning as helping him grow. Simms is pursuing a theater minor, which he says helps him in sports journalism because of the need to think quickly and be flexible doing live reporting.

Jake Garcia, the play-by-play announcer for the Wareham Gatemen, is back on the Cape for his second season. He is a rising senior in the accelerated master’s program at the Cronkite School.

Garcia is also from California and was “dead-set” on attending UCLA until he received a flier in the mail about the sports journalism program at ASU. When a high school baseball tournament was rained out, he and his dad took a road trip to ASU, he took a tour and the rest is history, he said.

The deciding factor for him was the Cronkite News studio and anchor desk. He said that seeing the Cronkite School’s commitment to giving students the best, most realistic experience possible made him decide to attend ASU.

He said it was a smart decision because “I’m getting exactly what I need,” including the professional training experience both in Arizona’s largest city, but also in the support for internships including this one at the Cape Cod Baseball League.

“It’s a fantastic experience, because it’s 44 games in about 50 days,” he said about his summer job. “You can’t duplicate those reps anywhere else. It’s a grind.”

Like Simms, he has had a number of opportunities that he doesn’t think he would get at other schools, including keeping spring training stats with Time Warner, ESPNU, or FOX, calling ASU baseball games through the Pac-12 network, and an internship with Scout Media covering ASU football.

“I kind of feel like a player,” he said. “They’re trying to improve their draft stock, and I’m trying to improve my resume reel. We’re both going to end up finding ourselves in minor league baseball eventually. I’m ready for the ride.”

Top photo: The Cape Cod Baseball League is a place where young ballplayers hone their skills, but emerging broadcasters such as Andre Simms (left) and Jake Garcia get practice, too. Photo by Logan Clark/ASU

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From worms to cancer cures

Fusing fundamental science, clinical research leads to better cancer-fight tools
July 5, 2016

ASU students, faculty strive to eradicate cancer at two collaborative labs in Piper Center for Personalized Diagnostics

The path from roundworm genes to curing cancer isn’t an easy one.

But a handful of students and faculty at Arizona State University are joining forces to increase our understanding of how small biological changes in genes can influence the development, diagnosis and treatment of cancer.

Two faculty laboratories within ASU’s Virginia G. Piper Center for Personalized Diagnostics — and the students who work there — are fusing fundamental science with clinical research to create more effective diagnostic and treatment options for multiple types of cancer.

“Neither of our labs could do this on our own,” said Dr. Karen Anderson, medical oncologist at Mayo Clinic Arizona and associate professor in the Biodesign Institute and School of Life Sciences. “We have the potential of thinking about the problem in a different way, and I think that’s really important.”

The collaborative effort and shift in thinking allow students like Justin Wolter, who’s pursuing a Doctor of Philosophy in molecular and cellular biology, to identify how biological mechanisms play a role in cancer development and progression.

Bianca Varda, an undergraduate in Anderson’s lab, has been utilizing Wolter’s expertise in molecular biology to develop new ways to activate the immune system to fight a specific strain of HPV before it leads to oropharyngeal cancer, which affects tissues in the throat such as the tongue and tonsils.

Their research, along with other lab initiatives, is part of finding innovative cures for diseases from some of the most unexpected places.

“Maintaining a balance between basic and translational research is really important to allow for fundamental discoveries that can be applied to human health,” said Wolter.

Worm to human genes

Wolter is on a team of researchers in assistant professor Marco Mangone’s lab who have been conducting experiments — using the roundworm as a model organism — to explore what key roles genes play in producing a variety of complex life forms, from fruit flies, to mice, to humans. The newfound understanding of this tiny worm’s genetics can then be translated to human cell lines when trying to determine how genes are broken in diseases.

“Cancer is an incredible model because essentially it’s just cells growing and dividing,” said Wolter. “The exact opposite of what they should be doing.”

Under the mentorship of Mangone, Wolter’s research has focused on two genes, known as microRNAs, that are relevant to breast cancer prognosis and progression. One gene limits tumor formation by slowing cell division and growth. The other gene triggers the transition from a benign tumor to the more aggressive metastatic form by allowing cells to break free and colonize at a new site in the body.

“What’s really interesting about these two genes is they’re tiny,” said Wolter. “How they regulate a large number of genes and give you such different behaviors, different phenotypes and different contributions to the disease is really unknown.”

Using evidence from the genomes of different animals, Wolter’s research aims to show how single mutations in these genes throughout the course of evolution can have an effect on human disease.

“There’s a lot of interest to study disease-relevant genes,” said Wolter. “So that’s a big motivational factor for me and our lab to try to look at ways we can modulate these genes or change when and where they’re expressed to combat some of the more severe forms of cancer.”

Lab at ASU Virginia G. Piper Center for Personalized Diagnostics

Two faculty laboratories within ASU’s Virginia G. Piper Center for Personalized Diagnostics — and the students who work there — are fusing fundamental science with clinical research to create more effective diagnostic and treatment options for multiple types of cancer. Photo by Esly Diaz/ASU

Translating basic research into cures

Anderson, who also serves as a faculty member on Wolter’s graduate committee, utilizes these types of findings from basic research to develop cancer detection and treatment options through immunology.

Researchers in Anderson’s lab have been studying how our immune systems can detect cancers based on small changes in our cells. Differences in proteins and other changes create biomarkers for different cancer types, which serve as another method for early disease detection.

“The real question right now is how early can we find these cancers,” said Anderson.

By measuring biomarkers in the blood specific to breast cancer, researchers in her lab have been working to develop a blood test that can be used with mammograms to find cancer earlier.

“We have a number of blood test-based biomarkers that are currently under investigation to determine how useful they might be clinically,” said Anderson.

Anderson’s team has also been examining how to change and activate the immune system to fight off cancer — a project undergraduate Bianca Varda has been working on solving for HPV-related cancers.

Varda, a biological sciences major in the School of Life Sciences and Barrett, the Honors College, has been studying how the immune system interacts with HPV 16 — one of a dozen types of high-risk HPVs that cause nearly 5 percent of all cancers worldwide. She has been engineering a system that will help measure and initiate an immune response to detect head, neck and cervical cancer.

HPV 16, along with HPV 18, is responsible for most HPV-caused cancers, including cervical, throat and anal cancers. In the U.S., more than 50 percent of cancer diagnoses in oropharynx (the middle part of the throat) are linked to HPV 16, while HPV 16 and 18 cause nearly 70 percent of all cervical cancer cases.

Varda’s work centers on activating the immune system by finding specific cellular protein, or peptide, sequences that trigger antigens, a molecule responsible for creating an immune response. Specifically, she’s looking to activate T cells, a type of white blood cell that assists in an active immune response.

“Right now we’re working on identifying specific peptide sequences that correspond to the HPV 16 antigens,” said Varda. “So we can stimulate T cells … and essentially use the immune system to fight off the cancer.”

“We need good researchers. They’re the future of our world.”
— Dawn Carson Senger, co-creator of the Carson Senger New American University Scholarship

Varda hopes her research will lead to the development of treatments for the millions of people infected with HPV, preventing the progression of HPV 16-related cancers.

“I got lucky to find a lab that’s doing something really interesting,” said Varda. “[But] without scholarships I wouldn’t be in the lab as much or at all.”

Funding student research experiences

Student research has been a long-time priority for two different families who have seen the devastating effects of cancer.

Dawn Carson Senger and Erston Senger, donors for Varda’s scholarship, established the Carson Senger New American University Scholarship to support a student with an interest in medical, biomedical or cancer research.

“We need good researchers,” said Carson Senger. “They’re the future of our world.”

John and Rose Maher, donors for Wolter’s scholarship, created the Maher Alumni Scholarship to support a graduate student pursuing cancer research while at ASU.

Affected by the loss of a friend and family member to the disease, John Maher said this was their answer to finding a cure for cancer and defeating it.

“Every single person we’ve sponsored with our scholarship has done a superb job with research, and Justin is continuing that terrific tradition,” said ASU alumnus John Maher. “He’s willing to work hard and get it done.”

Next steps

While the discovery of a simple cure for cancer is still underway, the research is already having a positive impact on Wolter and Varda.

After completing his doctorate, Wolter said he wants to stay in academia and run a lab at a university to continue his research in gene regulation and developmental biology.

Similarly, Varda wants to continue her research as a physician and is applying to medical school this spring.  

“I definitely plan to use and apply [my research] hopefully in the medical world,” said Varda. “I think it’s really important to understand the science behind the medicine you’re practicing.” 

The unyielding motivation and scientific curiosity of students in the lab are part of what makes the work worth it, said Anderson. 

“I like being able to educate the next generation of scientists,” she said. “They will solve this, I believe.” 

This story was published in the College of Liberal Arts and Sciences Magazine as part of the spring/summer 2016 issue.

Top photo: Graduate student Justin Wolter in professor Marco Magone's lab within ASU’s Virginia G. Piper Center for Personalized Diagnostics. Photo by Esly Diaz/ASU

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